NHTSA lists 2 safety recalls and 3 owner complaints for the 2025 Mercedes-Benz E 350 4Matic. Most complaints involve electrical system (2) and steering (1). The EPA rates it 27 mpg combined.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2025 E 350, E 350 4MATIC, E 450 4MATIC, and E450 4MATIC station wagon vehicles. The camber strut bracket may have been improperly welded onto the rear axle carrier, possibly resulting in separation of the bracket from the rear axle carrier.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2024-2026 AMG GT, C-Class, E-Class, SL, CLE, and GLC vehicles. The infotainment control unit may reset while the vehicle is in motion and cause the instrument panel display to go blank.
Complaints are unverified owner reports to NHTSA and are not normalized for sales volume. One complaint can cite several components.
Complaints for each E 350 4Matic model year we’ve synced.
Only one model year synced so far.
“Software issue: all screens go black without warning while driving. No access to speed, car temperature, a real safety issue. It’s like driving blind complete loss of controls. It was 98 degrees in Florida and suddenly the heater was blasting heat. My son, a passenger was unable to turn it off.”
“The steering and suspension system appears to be malfunctioning. The vehicle consistently pulls to the right during normal driving and does not track straight when the steering wheel is held centered. This condition requires constant steering correction and affects vehicle stability and control. My safety and the safety of others are put at risk, particularly at highway speeds or during emergency maneuvers, where unintended lane deviation may occur. The issue is repeatable and occurs on straight, flat roads at both city and highway speeds. The vehicle has been inspected multiple times by an authorized Mercedes-Benz dealership, including alignment checks, but the condition has not been corrected. No warning lights or dashboard messages were displayed prior to or during the occurrence of this issue. The vehicle remains available for inspection upon request.”
Towing, payload and dimensions aren’t in the EPA or NHTSA data, so we don’t list them.
| Version | City | Hwy | Comb. | Fuel / yr | CO₂ g/mi |
|---|---|---|---|---|---|
| E350 4matic Auto 9-spd, 4 cyl, 2.0 L, Turbo · All-Wheel Drive | 24 | 33 | 27 | $2,800 | 327 |
| Item | Miles | Time | Note |
|---|---|---|---|
| Engine oil & filter | 5,000–10,000 mi | 6–12 months | Follow the oil-life monitor if fitted |
| Tire rotation | 5,000–7,500 mi | Every oil change | Check pressure monthly |
| Engine air filter | 15,000–30,000 mi | 1–2 years | Sooner in dusty areas |
| Cabin air filter | 15,000–25,000 mi | 1–2 years | |
| Brake fluid | — | 2–3 years | Absorbs moisture over time |
| Coolant | 60,000–100,000 mi | 5–10 years | Long-life coolants last longer |
| Spark plugs | 60,000–100,000 mi | — | Iridium/platinum plugs at the long end |
| 12V battery | — | 3–5 years | Heat shortens battery life |
2 safety recalls as of Nov 12, 2026, according to NHTSA. Recall repairs are free at a dealer. Check your VIN to see whether your car is included and whether the repair was done.
Owners filed 3 complaints with NHTSA. The most-cited components are electrical system (2), steering (1), suspension (1). Complaints are unverified owner reports and aren't adjusted for how many cars were sold.
The EPA rates the 2025 Mercedes-Benz E 350 4Matic at 27 mpg combined, depending on engine and drivetrain (1 version rated).