Research · Small Sport Utility Vehicle 2WD

2021 Lexus RX 350Recalls, problems, MPG & safety

NHTSA lists 0 safety recalls and 71 owner complaints for the 2021 Lexus RX 350. Most complaints involve air bags (47) and structure (5). The EPA rates it 22–23 mpg combined, and NHTSA gives it 4–5 stars overall.

Combined MPG
22–23mpg
EPA · 2 versions
NHTSA overall
4–5of 5 stars
NCAP crash tests
Safety recalls
0campaigns
NHTSA
Owner complaints
71
Top: air bags
Fuel cost / yr
$2,700est.
EPA estimate, best version
01 —Recalls

Safety recalls

NHTSA campaigns for this model year
0 recalls found in NHTSA data for the 2021 Lexus RX 350 as of Nov 10, 2026.
Data from NHTSA Recalls API · synced Nov 10, 2026NHTSA vehicle page
02 —Complaints

Owner complaints by component

71 complaints filed with NHTSA · Dec 2020 – Sep 2026
  1. Air bags47
  2. Structure5
  3. Electrical system4
  4. Service brakes4
  5. Forward collision avoidance4
  6. Seat belts4
  7. Tires2
  8. Engine2
  9. Visibility/wiper1

Complaints are unverified owner reports to NHTSA and are not normalized for sales volume. One complaint can cite several components.

By model year

Complaints for each RX 350 model year we’ve synced.

View as table
Model yearNHTSA complaints
202055
202171
202239
202366
202462
202523
202611
Crashes reported
9
Fires reported
0
Injuries reported
9
Deaths reported
0
Data from NHTSA Complaints API · synced Nov 10, 2026 · Full problem breakdownNHTSA vehicle page
03 —Common problems

What owners report most

Verbatim excerpts from NHTSA complaints, by component

Air bags

47 reports3 crashes
“The contact owns a 2021 Lexus RX 350. The contact received notification of NHTSA Campaign Number: 23V865000 (Air Bags); however, the part to do the recall repair was not yet available. The local dealer was contacted. The contact stated that the manufacturer had exceeded a reasonable amount of time for the recall repair. The manufacturer was not made aware of the issue. The contact had not experienced a failure.”
Owner complaint to NHTSAFiled Dec 19, 2025Air bagsODI 11706097

Structure

5 reports2 crashes
“I was at the gas station, in line waiting for one of the three gas pumps to be available. I put my car in reverse to back up and pull around another car in order to go to the open pump in front. When my car was in reverse motion, I stepped on the brake pedal, but the car did not stop. I stepped on the brake pedal numerous times, but the brake did not function. My car backed into the front of the car in line behind me damaging both vehicles. The automatic emergency braking system did not activate, and there was no rear collision warning sound or message. I switched my car from Reverse into Park to stop its movement, but it was too late to avoid the collision. I had a passenger in my car who corroborates this description. Fortunately there were no pedestrians behind my car, so the only damage was to the vehicles. My vehicle has not been inspected by anyone since the accident, but will be soon. I have owned this car since April 2021 and previously had a few similar situations when moving in the forward direction. Previously, the brake problem occurred while moving forward at very low speed pulling into parking places. The brake failed to activate, and I had to…”
Owner complaint to NHTSAFiled Sep 3, 2025Structure, Service brakes, Forward collision avoidanceCrash reportedODI 11684842

Electrical system

4 reports
“Electronic Parking Brake (EPB), 12V Battery/Electrical System. My vehicle's 12V battery failed, with the dealership measuring voltage below 10V during the event. This caused multiple simultaneous module malfunctions (confirmed by the dealer as caused by the battery failure), including a complete inability to move the vehicle after jump-starting on three separate attempts — the engine ran, but the vehicle would not drive despite a functioning alternator. The vehicle's steering wheel also locked, preventing the car from being pushed to a safe location. Approximately 3 months after this event, a routine service visit revealed the rear brake pads had worn from 8mm (measured at time of purchase) to 2mm (failed), while the front pads wore from 10mm to 7.8mm (normal wear) over the same period and mileage. The rear pads wore roughly 3 times faster than the front, which is inconsistent with normal vehicle operation, since front brakes handle proportionally more braking load and are fitted with larger rotors for this reason on this and virtually all vehicles. The rear brake caliper is the only caliper equipped with the EPB motor/actuator; the front calipers are purely…”
Owner complaint to NHTSAFiled Sep 27, 2026Electrical system, Service brakesODI 11767292
Data from NHTSA Complaints API (owner reports, unverified) · synced Nov 10, 2026
04 —Key specs

Engines, transmissions & drive

2 versions rated by the EPA
EPA class
Small Sport Utility Vehicle 2WD, Small Sport Utility Vehicle 4WD
Engines
3.5L 6-cyl
Transmissions
Automatic (S8)
Drive
Front-Wheel Drive · All-Wheel Drive
Fuel
Regular Gasoline

Towing, payload and dimensions aren’t in the EPA or NHTSA data, so we don’t list them.

Data from EPA fueleconomy.gov · synced Nov 10, 2026EPA listing
05 —Fuel economy

EPA fuel economy by version

City / highway / combined, annual fuel cost and CO₂
EPA
VersionCityHwyComb.Fuel / yrCO₂ g/mi
RX 350
Auto (S8), 6 cyl, 3.5 L · Front-Wheel Drive
202723$2,700391
RX 350 AWD
Auto (S8), 6 cyl, 3.5 L · All-Wheel Drive
192622$2,850405
  • RX 350
    Auto (S8), 6 cyl, 3.5 L
    20 city · 27 hwy · $2,700/yr
    23
    mpg comb.
  • RX 350 AWD
    Auto (S8), 6 cyl, 3.5 L
    19 city · 26 hwy · $2,850/yr
    22
    mpg comb.
Data from EPA fueleconomy.gov · synced Nov 10, 2026 · Fuel cost is EPA’s annual estimate (15,000 mi, 55% city)
06 —Safety

NHTSA 5-Star Safety Ratings

4 tested variants
Overall rating
4/ 5
4 of 5
Lexus RX 350 SUV FWD Later Release
Frontal crash
4 of 5
Side crash
5 of 5
Side pole
5 of 5
Rollover
4 of 5
Rollover risk
17.9%
Overall
4 / 5
Lexus RX 350 SUV AWD Later Release
Frontal crash
4 of 5
Side crash
5 of 5
Side pole
5 of 5
Rollover
4 of 5
Rollover risk
16.4%
Overall
5 / 5
Lexus RX 350 SUV AWD Early Release
Frontal crash
4 of 5
Side crash
5 of 5
Side pole
5 of 5
Rollover
4 of 5
Rollover risk
16.4%
Overall
4 / 5
Lexus RX 350 SUV FWD Early Release
Frontal crash
4 of 5
Side crash
5 of 5
Side pole
5 of 5
Rollover
4 of 5
Rollover risk
17.9%
Data from NHTSA NCAP Safety Ratings API · synced Nov 10, 2026Vehicle 15959Vehicle 15958Vehicle 15842
07 —Maintenance

Maintenance basics

General guidance, not the OEM schedule. Check your owner’s manual.
General guidance
ItemMilesTimeNote
Engine oil & filter5,000–10,000 mi6–12 monthsFollow the oil-life monitor if fitted
Tire rotation5,000–7,500 miEvery oil changeCheck pressure monthly
Engine air filter15,000–30,000 mi1–2 yearsSooner in dusty areas
Cabin air filter15,000–25,000 mi1–2 years
Brake fluid—2–3 yearsAbsorbs moisture over time
Coolant60,000–100,000 mi5–10 yearsLong-life coolants last longer
Spark plugs60,000–100,000 mi—Iridium/platinum plugs at the long end
12V battery—3–5 yearsHeat shortens battery life
  • Engine oil & filter5,000–10,000 mi
    6–12 months
  • Tire rotation5,000–7,500 mi
    Every oil change
  • Engine air filter15,000–30,000 mi
    1–2 years
  • Cabin air filter15,000–25,000 mi
    1–2 years
  • Brake fluid—
    2–3 years
  • Coolant60,000–100,000 mi
    5–10 years
  • Spark plugs60,000–100,000 mi
    —
  • 12V battery—
    3–5 years
Typical intervals for modern cars. Severe service (towing, short trips, extreme heat or cold) shortens them.
09 —FAQ

2021 RX 350 questions

How many recalls does the 2021 Lexus RX 350 have?

0 recalls found in NHTSA data as of Nov 10, 2026.

What are the most common 2021 Lexus RX 350 problems?

Owners filed 71 complaints with NHTSA. The most-cited components are air bags (47), structure (5), electrical system (4). Complaints are unverified owner reports and aren't adjusted for how many cars were sold.

What MPG does the 2021 Lexus RX 350 get?

The EPA rates the 2021 Lexus RX 350 at 22–23 mpg combined, depending on engine and drivetrain (2 versions rated).

How safe is the 2021 Lexus RX 350?

NHTSA's New Car Assessment Program gives the 2021 Lexus RX 350 4–5 out of 5 stars overall.

Data from NHTSA & EPA · synced Nov 10, 2026