NHTSA lists 1 safety recall and 3 owner complaints for the 2020 Mercedes-Benz E 450 4Matic. Most complaints involve power train (1) and engine (1). The EPA rates it 22–23 mpg combined.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018 E 400 4MATIC Sedan, E 400 4MATIC Wagon, E 400 4MATIC Cabriolet, E 400 4MATIC Coupe, 2018-2020 Maybach S 560 4MATIC, S 560 4MATIC Coupe, S 450 4MATIC, 2019-2020 E 450 4MATIC Sedan, E 450 4MATIC Wagon, E 450 4MATIC Coupe, and E 450 4MATIC Cabriolet vehicles. The drive shaft universal joint may break, resulting in a sudden loss of drive power.
Complaints are unverified owner reports to NHTSA and are not normalized for sales volume. One complaint can cite several components.
“The contact owns a 2020 Mercedes-Benz E450 4Matic. While the contact’s son was driving at an undisclosed speed, the vehicle unexpectedly slowed down and failed to properly accelerate. The contact's son attempted to shift into reverse; however, the transmission was making an abnormal grinding sound. The vehicle was towed to the dealer to be diagnosed. The vehicle was diagnosed with drivetrain and engine damage, catalytic converter failure, and a bolt had snapped or was loose. The contact stated that the dealer related the failure to NHTSA Campaign Number: 26V216000 (POWER TRAIN). The vehicle was not repaired. The part to do the recall repair was not yet available. The contact stated that the manufacturer had exceeded a reasonable amount of time for the recall repair. The manufacturer was made aware of the issue. The failure mileage was approximately 78,000.”
“My 2020 E450 has not been serviced on schedule due to Mercedes-Benz of Indianapolis and its service manger banning and blacklisting me for months. This service department would not allow my vehicle to be serviced under a prepaid maintenance and wheel and tire plan, and most importantly my vehicle's warranty. When I went there for an appointment, a flat tire, or help with my vehicle, they kicked me out, verbally harassed and threatened me because I did not pay the deductible on a loaner vehicle because my signature was forged to submit a false claim. I have had problems with my vehicle, but most recently, as I was driving on a roundabout in rush hour traffic, when my vehicle suddeny stopped and experienced lack of compulsion and would not drive. It had already had a check light engine, tires, batteries, and brakes. It was surprising because my 2020 E450 Mercedes-Benz had only 39,000 miles. I did not have anywhere to take it to. Mercedes-Benz Customer Care authorized it to be towed to the Mercedes-Benz of Fort Wayne because the service manager black listed me from surrounding MercedesBenz service departments. When my vehicle was towed to Fort Wayne, the service…”
Towing, payload and dimensions aren’t in the EPA or NHTSA data, so we don’t list them.
| Version | City | Hwy | Comb. | Fuel / yr | CO₂ g/mi |
|---|---|---|---|---|---|
| E450 4matic Auto 9-spd, 6 cyl, 3.0 L, Turbo · 4-Wheel Drive | 20 | 28 | 23 | $3,250 | 392 |
| E450 4matic (station wagon) Auto 9-spd, 6 cyl, 3.0 L, Turbo · 4-Wheel Drive | 19 | 26 | 22 | $3,400 | 408 |
| E450 4matic Convertible Auto 9-spd, 6 cyl, 3.0 L, Turbo · 4-Wheel Drive | 19 | 26 | 22 | $3,400 | 408 |
| E450 4matic Coupe Auto 9-spd, 6 cyl, 3.0 L, Turbo · 4-Wheel Drive | 19 | 26 | 22 | $3,400 | 409 |
| Item | Miles | Time | Note |
|---|---|---|---|
| Engine oil & filter | 5,000–10,000 mi | 6–12 months | Follow the oil-life monitor if fitted |
| Tire rotation | 5,000–7,500 mi | Every oil change | Check pressure monthly |
| Engine air filter | 15,000–30,000 mi | 1–2 years | Sooner in dusty areas |
| Cabin air filter | 15,000–25,000 mi | 1–2 years | |
| Brake fluid | — | 2–3 years | Absorbs moisture over time |
| Coolant | 60,000–100,000 mi | 5–10 years | Long-life coolants last longer |
| Spark plugs | 60,000–100,000 mi | — | Iridium/platinum plugs at the long end |
| 12V battery | — | 3–5 years | Heat shortens battery life |
1 safety recall as of Nov 13, 2026, according to NHTSA. Recall repairs are free at a dealer. Check your VIN to see whether your car is included and whether the repair was done.
Owners filed 3 complaints with NHTSA. The most-cited components are power train (1), engine (1), fuel/propulsion system (1). Complaints are unverified owner reports and aren't adjusted for how many cars were sold.
The EPA rates the 2020 Mercedes-Benz E 450 4Matic at 22–23 mpg combined, depending on engine and drivetrain (4 versions rated).