NHTSA lists 1 safety recall and 5 owner complaints for the 2019 Mercedes-Benz E 450 4Matic. Most complaints involve power train (4) and electrical system (1). The EPA rates it 22–23 mpg combined.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018 E 400 4MATIC Sedan, E 400 4MATIC Wagon, E 400 4MATIC Cabriolet, E 400 4MATIC Coupe, 2018-2020 Maybach S 560 4MATIC, S 560 4MATIC Coupe, S 450 4MATIC, 2019-2020 E 450 4MATIC Sedan, E 450 4MATIC Wagon, E 450 4MATIC Coupe, and E 450 4MATIC Cabriolet vehicles. The drive shaft universal joint may break, resulting in a sudden loss of drive power.
Complaints are unverified owner reports to NHTSA and are not normalized for sales volume. One complaint can cite several components.
“The contact owns a 2019 Mercedes-Benz E-450 4MATIC. The contact stated that while driving 35 MPH, the brake pedal was depressed, and the vehicle vibrated abnormally. The dealer was contacted by phone and made aware of the failure. The vehicle was taken to the dealer where the brakes and throttle body were repaired. The vehicle was repaired; however, the failure reoccurred. The vehicle was taken back to the dealer where it was confirmed that the failure was associated with an unrepaired recall. The contact received notification of NHTSA Campaign Number: 26V216000 (Power Train); however, the part was unavailable for the recall repair. The manufacturer was contacted by phone and a case was filed. The failure mileage was approximately 17,500.”
“Vehicle was exhibiting erratic indications in all safety systems. Was checked out by dealer told all was OK. Two weeks later vehicle indicated warnings in various safety system, instrument cluster went dark, speedometer and tach were inop, blinkers did not work. Car taken to dealer again where it was determined that water incursion into passenger side foot well as the result of clogged sunroof drains had resulted in water damage to the signal acquisition module and other modules regulating the CAN Bus which were mounted in a location susceptible to water incursion and damage. Routine service does not include assuring that sunroof drains are open. Given the nature of computer systems in this vehicle such water damage has the potential of serious safety issues. These modules must be relocated to an area not prone to flooding. MBNA was contacted and provided no customer support whatsoever. The repair was almost $2500.”
Towing, payload and dimensions aren’t in the EPA or NHTSA data, so we don’t list them.
| Version | City | Hwy | Comb. | Fuel / yr | CO₂ g/mi |
|---|---|---|---|---|---|
| E450 4matic Auto 9-spd, 6 cyl, 3.0 L, Turbo · 4-Wheel Drive | 20 | 28 | 23 | $3,250 | 392 |
| E450 4matic (station wagon) Auto 9-spd, 6 cyl, 3.0 L, Turbo · 4-Wheel Drive | 19 | 26 | 22 | $3,400 | 408 |
| E450 4matic Convertible Auto 9-spd, 6 cyl, 3.0 L, Turbo · 4-Wheel Drive | 19 | 26 | 22 | $3,400 | 408 |
| E450 4matic Coupe Auto 9-spd, 6 cyl, 3.0 L, Turbo · 4-Wheel Drive | 19 | 26 | 22 | $3,400 | 409 |
| Item | Miles | Time | Note |
|---|---|---|---|
| Engine oil & filter | 5,000–10,000 mi | 6–12 months | Follow the oil-life monitor if fitted |
| Tire rotation | 5,000–7,500 mi | Every oil change | Check pressure monthly |
| Engine air filter | 15,000–30,000 mi | 1–2 years | Sooner in dusty areas |
| Cabin air filter | 15,000–25,000 mi | 1–2 years | |
| Brake fluid | — | 2–3 years | Absorbs moisture over time |
| Coolant | 60,000–100,000 mi | 5–10 years | Long-life coolants last longer |
| Spark plugs | 60,000–100,000 mi | — | Iridium/platinum plugs at the long end |
| 12V battery | — | 3–5 years | Heat shortens battery life |
1 safety recall as of Nov 12, 2026, according to NHTSA. Recall repairs are free at a dealer. Check your VIN to see whether your car is included and whether the repair was done.
Owners filed 5 complaints with NHTSA. The most-cited components are power train (4), electrical system (1), forward collision avoidance (1). Complaints are unverified owner reports and aren't adjusted for how many cars were sold.
The EPA rates the 2019 Mercedes-Benz E 450 4Matic at 22–23 mpg combined, depending on engine and drivetrain (4 versions rated).